The Wickersham Brothers are major antagonists in Dr. Seuss' 1954 children's book Horton Hears a Who!. They are a gang of hundreds of monkeys who try to intimidate the titular protagonist, Horton the Elephant, into renouncing the existence of the Whos of Whoville, which upsets the social order of the jungle. They serve as the enforcers of the main antagonist, Sour Kangaroo.
They are symbolic of Cold War paranoia, conformity, and social ostracism of those who are different.